Modern concept — renal continuum (acute kidney injury, acute kidney disease, chronic kidney disease)

Acute kidney injury and chronic kidney disease.

Yin and Yang: acute kidney injury and chronic kidney disease.

establish ultrasonographic criteria in patients who have unknown genotype and are at risk for ADPKD. Moreover, the results demonstrate that the diagnostic criteria currently in use for PKD1 may be inaccurate when applied to PKD2 because of higher risks for false-negative results yielding a reduced sensitivity for individuals aged 15 to 59. In summary, the authors propose new ultrasound diagnost...

Acute kidney injury: gateway to chronic kidney disease.

This review examines the evidence linking acute kidney injury (AKI) with the risk of subsequently developing chronic kidney disease (CKD). The discussion focuses on subjects that recover from an episode of AKI, most of whom do not receive follow-up nephrology care. Many recent studies have shown a strong association between AKI and the risk of developing CKD. Preclinical models provide evidence...

Acute kidney injury and chronic kidney disease as interconnected syndromes.

From the Department of Medicine, Divi­ sion of Intensive Care Medicine, and the Division of Nephrology, Washington, DC, Veterans Affairs Medical Center (L.S.C.), and the Department of Anesthesiology and Critical Care Medicine (L.S.C.) and Department of Medicine, Division of Renal Diseases and Hypertension (L.S.C., P.L.K.), George Washington University Medical Center — both in Washington, DC; an...

Insights into the Mechanisms of the Acute Kidney Injury-to-Chronic Kidney Disease Continuum.

Acute kidney injury (AKI) is an increasingly common clinical problem with significant impact on long-term patient outcome. Recent clinical trials demonstrate that AKI is closely related to the progression of chronic kidney disease (CKD) and end-stage renal disease, though the precise mechanisms linking AKI to CKD remain unclear. While inflammation, microvascular rarefaction and hypoxia are invo...